ODCs

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1 OMIM reference -
2 associated genes
16 signs/symptoms

COMMON GENES: 1
COMMON SIGNS: 11

3 OMIM references -
4 associated genes
12 signs/symptoms

Juvenile primary lateral sclerosis

Juvenile amyotrophic lateral sclerosis

Citations in the biomedical literature:

Juvenile primary lateral sclerosis		Juvenile amyotrophic lateral sclerosis
	Synonym(s): - JPLS - Juvenile PLS		Synonym(s): - JALS - Juvenile Charcot disease - Juvenile Lou Gehrig disease

	Classification (Orphanet): - Rare genetic disease - Rare neurologic disease		Classification (Orphanet): - Rare genetic disease - Rare neurologic disease

	Classification (ICD10): - Diseases of the nervous system -		Classification (ICD10): - Diseases of the nervous system -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: any age Type of inheritance: autosomal recessive		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: adult Type of inheritance: autosomal recessive

	External references: 1 OMIM reference - 1 MeSH reference: C536416		External references: 3 OMIM references - No MeSH references


COMMON SIGNS	- Abnormal gait - Autosomal recessive inheritance - Bladder and ureter anomalies - Elocution disorders / dysarthria / dysphonia - Hypereflexia - Hypertonia / spasticity / rigidity / stiffness - Motor deficit / trouble - Muscle hypotrophy / atrophy / dystrophy / agenesis / amyotrophy - Pseudobulbar signs / spasmodic laugh and cry - Pyramidal syndrome - Sensitive trouble / deficit

Juvenile primary lateral sclerosis		Juvenile amyotrophic lateral sclerosis
	Very frequent - Ataxia / incoordination / trouble of the equilibrium - Hemiplegia / diplegia / hemiparesia / limb palsy - Muscle weakness / flaccidity Frequent - Feeding disorder / dysphagia / swallowing / sucking disorder / esophageal dyskinesia - Speech troubles / aphasia / dysphasia / echolalia / mutism / logorrhea / dysprosodia		Very frequent - Abnormal EMG / electromyogram / electropmyography